The fusion of artificial intelligence with medical imaging is undoubtedly a progressive innovative process in the modern development of domestic healthcare, which allows for unprecedented accuracy and efficiency in the diagnosis and planning of special treatment of various diseases, including malignant tumors. At the same time, artificial intelligence approaches, especially in the field of clinical application of radiotherapy techniques, are spreading more widely and moving from the field of specialized research to the field of already accepted traditional clinical practice. Purpose of the study: to analyze the approaches of artificial intelligence in the field of clinical application of radiotherapy techniques for the antitumor treatment of malignant tumors. Conclusion. The further development of artificial intelligence provides for the provision of options for the prevention, diagnosis and treatment of cancer patients against the background of a constant increase in accuracy in their implementation, including assistance in optimizing radiotherapeutic treatment of malignant neoplasms. © 2025 Elsevier B.V., All rights reserved.