Peculiarities of Blood Iron Balance During Arterial Hypertension Recovery According to the Centralized Aerobic-Anaerobic Balance Compensation

The novel theory of centralized aerobic-anaerobic balance compensation (TCAAEBC) connects the acute rise of blood pressure (BP) and arterial hypertension (AHT) onset with the restriction(s) to arterial blood to deliver some information to the rhomboid fossa. Recently, it was demonstrated that TCAAEBC is useful to explain the development of various noncommunicable diseases (NCDs). According to the theory, the misinterpreting of the available information about oxygen availability causes the CAAEBC system in our body to compensate. Then, this compensation initially causes AHT and later leads to an avalanche of subsequent NCDs. The iron (Fe)-containing protein, hemoglobin (Hb), is the major player in the oxygen-supply story. For this reason, according to TCAAEBC, Hb concentration ([Hb]) as well as the volume percentage of red blood cells [hematocrit (HCT)] are indexes not only of iron concentration ([Fe]) in blood but also of AHT recovery. We discussed original data on these indexes, obtained in our clinic during AHT recovery. © 2025 Elsevier B.V., All rights reserved.