APPLICATION OF EXTRACORPOREAL DETOXIFICATION METHODS IN THE COMPLEX TREATMENT OF PATIENTS WITH INFECTED PANCREATIC NECROSIS

Objective: To investigate the effect of extracorporeal detoxification methods (ECDM) on the effectiveness of treatment in patients with infected pancreatic necrosis (IPN). Methods: To assess the effectiveness of the applied treatment methods, we applied prospective and retrospective analyses of clinical outcomes in 88 patients diagnosed with IPN. Among all participants, 67 patients (76%) were males and 21 (24%) were females. The age of patients ranged from 18 to 82 years, with a mean of 48.6±1.2 years. To evaluate the impact of ECDM on the effectiveness of IPN treatment, we divided patients into two groups. The main group (Group 1), consisting of 53 patients (60%), received standard conservative and surgical treatment supplemented by extracorporeal detoxification procedures. The control group (Group 2), comprising of 35 patients (40%), were treated without application of ECDM. Statistical data analysis was performed using IBM SPSS Statistics 17.0 (USA). Results: The use of extracorporeal detoxification procedures in the therapeutic complex for patients with IPN contributed to the improvement of leukocyte count, band neutrophils, and leukocyte intoxication index (LII), and also led to a more pronounced reduction in blood biochemistry indicators (urea, creatinine, glomerular filtration rate (GFR), α-amylase), which, together with a decrease in the mean APACHE II score, indicated a significant improvement in the general condition of patients. Conclusion: The group of patients receiving ECDM in the comprehensive treatment had a more favourable course of pathology, as demonstrated by the shortened resolution time of local and systemic manifestations of the disease. © 2025 Elsevier B.V., All rights reserved.