Modern enterosorbents in pediatric practice: new therapy possibilities; Современные энтеросорбенты в педиатрической практике: новые возможности в терапии

Enterosorbents are one of the most commonly used groups of drugs in pediatric practice with sorption and detoxification properties. The efficacy of this group of drugs is due to the ability of enterosorbents not to break down in the gastrointestinal tract, to bind and remove exogenous and endogenous substances, various metabolic products, microorganisms and their toxins from the body, which allows them to be used in various nosologies. The article presents current data on enterosorbents, their classification by dosage form and field of application, and provides examples of pathogenetic activity in therapy for various diseases in children, including food allergies, the prevalence of which in children varies from 3 to 35% in various age groups. According to international statistics, the highest prevalence of food allergies is observed in children of early and preschool age. In most preschool children, atopic dermatitis is a consequence of food allergies, hypersensitivity to various proteins, and the first stage in the start of the atopic march (atopic dermatitis — allergic rhinitis — bronchial asthma). The use of modern enterosorbents in groups of patients with various types of food sensitization is the main part of effective complex therapy and prevention of complications in allergic diseases. The article discusses the pathophysiological mechanisms of the formation of disorders and the possibility of effective use of enterosorbents in endogenous intoxication, taking into account the anatomical and physiological characteristics of childhood. © 2025 Elsevier B.V., All rights reserved.