Suppression of growth and metastasizing of T-Cell lymphoma in mice infected with American trypanosomiasis at different stages of experimental infection

Antitumor activity of Trypanosoma cruzi CH4 strain isolated in Mexico was studied. This parasite is not tumoritropic, but inhibits the growth and metastasizing of solid L5178Y-R lymphoma transplanted to Balb/C mice. Conditioned medium from cell cultures infected with this strain produced a cytostatic effect. Possible mechanisms of this phenomenon are discussed. © 2004 Plenum Publishing Corporation.