Arrhenius Kinetics As a Bioactivity Assessment Criterion for Drug Substances and Excipients

Arrhenius kinetic principles, in particular, Ea values, were used to assess the biological activity of drug substances in aqueous solutions with different D/H ratios. The obtained activation energies indicated that deuterium-depleted solutions had lower toxicity and biological activity. © 2016, Springer Science+Business Media New York.