Domino reaction of N-(cyanomethyl)-1,3-azolium quaternary salts with o-hydroxybenzaldehydes: Scope and limitations

A route towards chromenes, annulated with an imidazo[5,1-c][1,4]thiazine core through a base-promoted domino reaction of thiazolium quaternary salts, has been developed. The synthesised compounds show high cytotoxic activity against human tumour cell lines. This journal is © The Royal Society of Chemistry 2015.

Авторы
Voskressensky L.G. 1 , Festa A.A. 1 , Storozhenko O.A. 1 , Le T.A. 2 , Nguyen V.T. 3 , Varlamov A.V. 1
Журнал
RSC Advances
Номер выпуска
16
Язык
Английский
Страницы
12442-12445
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1039/C4RA14122A
Том
5
Год
2015
Организации
  • 1 Organic Chemistry Department, Peoples' Friendship University of Russia, Miklukho-Maklaya st., 6., Moscow, 117198, Russian Federation
  • 2 Department of Chemistry, Vietnam National University, 144 Xuan Thuy, Cau Giay, Hanoi, Viet Nam
  • 3 Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam
Ключевые слова
Cell culture; Cytotoxicity; Salts; Chromenes; Cytotoxic activities; Domino reactions; Hydroxybenzaldehydes; Quaternary salts; Synthesised; Tumour cells; Reaction kinetics
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