The first example of 4,7,8,9-tetrahydrothieno-[2,3-d]azocine synthesis by domino reaction of 4-aryl-4,5,6,7-tetrahydrothieno[3,2-c]pyridines with activated alkynes

1-Aryl-substituted tetrahydrothieno[3,2-c]pyridines easily undergo domino reactions with activated alkynes, giving good yields of the corresponding tetrahydrothieno[2,3-d]azocines. The reactions of 1-methyl-substituted tetrahydrothieno[3,2-c]pyridine were more complicated. © 2014 Springer Science+Business Media New York.