New trends in the development of antihistamines and immunoactive drugs: possible role of histamine H3/H4 receptors as a target for new classes of drugs

Histamine plays ат important role in the pathophysiology of allergic diseases, asthma, rhinitis and urticaria. The goal of this study was to investigate the different immune activities of a dual antagonists of H3 and H4 histamine receptors and on the possible role of a new types of histamine receptors as targets for the development of a new classes of antiallergic, immunoactive drugs.