Synthesis of 3,4-diaryl-5-carboxy-4,5-dihydroisoxazole 2-oxides as valuable synthons for anticancer molecules

The convenient regioselective scalable synthesis of 3,4-diaryl-5-carboxy-4,5-dihydroisoxazole 2-oxides was developed based on a condensation of simple starting materials (arylbenzaldehydes, arylnitromethanes, and ethoxycarbonylmethylpyridinium bromide) under mild conditions. The obtained synthons can be applied for the synthesis of 3,4-diarylisoxazole derivatives capable of suppressing malignant growth. © 2017 Elsevier Ltd

Авторы
Chernysheva N.B. 1 , Maksimenko A.S. 1 , Andreyanov F.A. 1 , Kislyi V.P. 1 , Strelenko Y.A. 1 , Khrustalev V.N. 2, 3 , Semenova M.N. 4 , Semenov V.V. 1
Журнал
Tetrahedron
Номер выпуска
48
Язык
Английский
Страницы
6728-6735
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1016/J.TET.2017.10.016
Том
73
Год
2017
Организации
  • 1 N. D. Zelinsky Institute of Organic Chemistry, RAS, 47 Leninsky Prospect, Moscow, 119991, Russian Federation
  • 2 Faculty of Science, RUDN University, 6 Miklukho-Maklay Street, Moscow, 117198, Russian Federation
  • 3 A. N. Nesmeyanov Institute of Organoelement Compounds, RAS, 28 Vavilov Street, Moscow, 119991, Russian Federation
  • 4 N. K. Koltzov Institute of Developmental Biology, RAS, 26 Vavilov Street, Moscow, 119334, Russian Federation
Ключевые слова
3,4-Diarylisoxazoles; 3,4-Diarylisoxazoline oxides; Anticancer synthons; Carbonylmethylpyridinium
Цитировать
ГОСТ MLA RIS BibTex
Поделиться

Другие записи