New Synthesis of Functionalized Nicotinamides

An efficient method has been developed for the synthesis of 6-(alkylsulfanyl)-4-aryl(hetaryl)-N-aryl-5-cyano-2-methylpyridine-3-carboxamides by condensation of aromatic or heteroaromatic aldehydes with cyanothioacetamide and acetoacetanilides in the presence of triethylamine or morpholine, followed by S-alkylation. © 2019, Pleiades Publishing, Ltd.

Авторы
Dyachenko I.V. 1 , Kalashnik I.N. 1 , Dyachenko V.D. 1 , Dorovatovskii P.V. 2 , Khrustalev V.N. 2, 3 , Nenajdenko V.G. 4
Журнал
Russian Journal of Organic Chemistry
Номер выпуска
7
Язык
Английский
Страницы
1019-1033
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1134/S1070428019070194
Том
55
Год
2019
Организации
  • 1 Taras Shevchenko Lugansk National University, Lugansk, Ukraine
  • 2 “Kurchatov Institute” National Research Center, Moscow, Russian Federation
  • 3 Peoples’ Friendship University of Russia, Moscow, Russian Federation
  • 4 Faculty of Chemistry, Moscow State University, Moscow, Russian Federation
Ключевые слова
acetoacetanilides; alkylating agents; aromatic and heteroaromatic aldehydes; cyanonicotinamides; cyanothioacetamide; X-ray analysis
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