Rh(III)-Catalyzed C−H Activation/Annulation of Aryl Hydroxamates with CF3-Containing α-Propargyl α-Amino Acid Derivatives

A series of new orthogonally protected α-CF3-substituted α-amino carboxylates, and α-amino phosphonates decorated with pharmacophore isoquinolone core has been elaborated through the Rh(III)-catalyzed C−H activation/annulation of aryl hydroxamates with propargyl-containing α-amino acid derivatives and their phosphorus analogues. © 2021 Wiley-VCH GmbH