Green synthesis of polysubstituted pyrroles through a domino sequence of aza-Claisen rearrangement/nucleophilic addition/oxidation/acylation

A pseudo three-component reaction of 2-imidazolines with electron-deficient alkynes furnishes 1,2,2,3-tetrasubstituted imidazolidines containing N-vinylpropargylamine moiety. Heating imidazolidines in aerobic conditions in butyl acetate solution leads to highly functionalized pyrroles through aza-Claisen rearrangement/nucleophilic addition/oxidation/acylation. © 2022 Author(s).