Rational sequence of monoclonal antibodies in the treatment of non-resectable head and neck squamous cell carcinoma [Рациональная последовательность моноклональных антител в лечении нерезектабельного плоскоклеточного рака головы и шеи]

This article discusses current approaches to first-line chemotherapy for non-resectable head and neck squamous cell carcinoma and describes factors affecting the choice of treatment regimen according to the results of randomized clinical trials. we provide a rationale for creating a long-term strategy of chemotherapy in different clinical situations. we also report two cases of concomitant administration of cetuximab and platinum-based therapy as an example of high efficacy of monoclonal antibodies. © 2022 Farmatsiya i Farmakologiya. All rights reserved.