HETEROCYCLIC CARBONITRILE CARBOXAMIDES AS A NEW CYTOSTATIC

The reaction of Pyruvic acid with 1,1,2,2-Tetracarbonitrilethane was the first to synthesize the corresponding Tricarboxamido derivative. The cyclization product of the intermediate -2-amino-5-methyl-3,4-dicyano-4,5-dihydrofuran-4,5-dicarboxamide was isolated. Their possibilities of "landing" on a promising nanocarrier - nanodiamonds, as well as cytostatic properties were studied.