EFFECT OF HIGH AND LOW-DOSES OF VITAMIN-A AND VITAMIN-E ON FROG CARDIOMYOCYTE EXCITABILITY

Lipid-soluble vitamins A (retinol) and E (tocopherol) are components of the natural antioxidant system of the cell. Vitamin A is known as a labilizer of lysosomal membranes, vitamin E (depending on its concentration) as a labilizer and stabilizer of these membranes [1-4]. The aim of this investigation was to study the electrophysiological characteristics of cardiomyocytes exposed to the action of a combination of these vitamins. It was assumed that, being lysosomotrophic, tocopherol and retinol ought to influence the properties of the cell membrane, and specifically its ionic permeability.