Effects of Fractionated Proton Irradiation in Combination with 1-β-D-Arabinofuranosylcytosine on B16 Murine Melanoma In Vivo

This study is a search for means of sensitization of malignant tumors to proton radiation among DNA damage repair inhibitors. It has been found that in the presence of 1-β-D-arabinofuranosylcytosine (AraC), five weekly proton irradiations at a total focal dose of 50 Gy lead to a more pronounced inhibition of B16 murine melanoma growth than the same irradiation without AraC (p < 0.05 ). This effect, associated with a decrease in the proliferative activity of cells in the general population and a decrease in the number of cancer stem cells specifically in the AraC+Protons group, is promising for further improvement of proton radiotherapy.

Авторы
Zamulaeva I.A. 1, 2 , Matchuk O.N. 1, 2 , Selivanova E.I. 1 , Mosina V.A. 1 , Abramova M.R. 1 , Saburov V.O. 1 , Koryakin S.N. 1 , Ivanov S.A. 1, 3 , Kaprin A.D. 3, 4, 5 , Boreyko A.V. 2 , Chausov V.N. 2 , Krasavin E.A. 2
Журнал
Physics of Particles and Nuclei Letters
Издательство
Pleiades Publishing, Ltd.
Номер выпуска
6
Язык
Английский
Страницы
1208-1218
Статус
Опубликовано
Том
21
Год
2024
Организации
  • 1 A. Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
  • 2 Joint Institute for Nuclear Research
  • 3 RUDN University
  • 4 National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
  • 5 P. Hertsen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Ключевые слова
proton radiation; melanoma; radiosensitizer; 1-β-D-arabinofuranosylcytosine (AraC); cancer stem cells
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